Tesi etd-05192025-225340
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Tipo di tesi
Corso Ordinario Ciclo Unico 6 Anni
Autore
NUTI, ANDREA
URN
etd-05192025-225340
Titolo
Effects of non-invasive temporal interference stimulation on the striatum during effort-based decision making
Struttura
Classe Scienze Sperimentali
Corso di studi
SCIENZE MEDICHE - SCIENZE MEDICHE
Commissione
relatore Prof. LIONETTI, VINCENZO
Relatore Prof. HUMMEL, FRIEDHELM
Presidente Prof. PASSINO, CLAUDIO
Membro Prof. GIANNONI, ALBERTO
Membro Dott.ssa TOGNINI, PAOLA
Membro Dott. AIMO, ALBERTO
Relatore Prof. HUMMEL, FRIEDHELM
Presidente Prof. PASSINO, CLAUDIO
Membro Prof. GIANNONI, ALBERTO
Membro Dott.ssa TOGNINI, PAOLA
Membro Dott. AIMO, ALBERTO
Parole chiave
- Anterior Cingulate Cortex
- Effort-based Decision Making
- Nucleus Accumbens
- Striatum
- Transcranial Temporal Interference Stimulation
Data inizio appello
20/06/2025;
Disponibilità
parziale
Riassunto analitico
Apathy, characterized by a reduction in goal-directed behavior, is a transdiagnostic syndrome prevalent across various neuropsychiatric conditions. Core neural correlates of effort-based decision making (EBDM) – a domain often impaired in apathy – include the ventral striatum (primarily the nucleus accumbens, NAcc), anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), supplementary motor area (SMA), and anterior insula. These regions collectively encode reward valuation, effort cost, and the computation of net value. In this study, we applied temporal interference (TI) stimulation to the striatum of healthy young participants to causally probe its role in EBDM. Behavioral results showed that continuous theta burst stimulation (cTBS) led to increased reaction times (RTs) in an EBDM task compared to high-frequency stimulation (HF) and intermittent theta burst stimulation (iTBS). Diffusion-weighted imaging revealed a significant correlation between individual differences in structural connectivity between ACC and NAcc and the behavioral effect of cTBS. Stronger NAcc-ACC connectivity was associated with greater cTBS-induced reduction of RTs relative to both iTBS and HF control. These findings suggest that modulating striatal activity via TI stimulation influences EBDM behavior, potentially through NAcc-ACC pathways and provides initial evidence supporting the striatal targeting of noninvasive stimulation as a promising neuromodulatory strategy for addressing apathy-related deficits in goal-directed behavior.
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