Tesi etd-05192026-123752
Link copiato negli appunti
Tipo di tesi
Corso Ordinario Ciclo Unico 6 Anni
Autore
PAPARELLA, FRANCESCO
URN
etd-05192026-123752
Titolo
Measles outbreaks: clinical analysis and emergency department management
Struttura
Classe Scienze Sperimentali
Corso di studi
SCIENZE MEDICHE - SCIENZE MEDICHE
Relatori
relatore Prof. LIONETTI, VINCENZO
relatore Dott. DIPAOLA, GIUSEPPE
relatore Dott. SORIANO, PIETRO
relatore Dott. DIPAOLA, GIUSEPPE
relatore Dott. SORIANO, PIETRO
Parole chiave
- C-reactive protein
- emergency department
- hospitalization
- isolation
- Measles
- outbreak
- vaccination
Data inizio appello
22/06/2026;
Disponibilità
parziale
Riassunto analitico
The measles virus is a highly contagious infective agent transmitted by aerosol or droplets. Due to the high contagiousness, the immunity threshold required to avoid measles outbreaks is above 90%. It remains a major public health concern despite the availability of effective vaccination programs. In 2024 an increase in measles cases was recorded in Italy, with outbreaks continuing till early 2026.
This study describes 17 laboratory-confirmed measles cases presenting to an Emergency Department in Barletta during the 2025–2026 outbreak. Data were collected from platforms used by the Emergency Department: Edotto, T-Health Net and AGFA healthcare. Chi-square test was used to assess correlation between laboratory parameters and hospitalization.
These cases were assessed for demographic, clinical, laboratory, radiological, and management characteristics Patients were mainly young adults, all but one were not vaccinated. The great majority of patients had flu-like symptoms, fever being the most frequent sign, and presented to the Emergency Department with the characteristic maculopapular rash. Hepatic involvement was frequent, with elevated transaminases in over 80% of cases, though these were not associated with hospitalization. In contrast, elevated C-reactive protein (≥5 mg/dL) showed a strong association with inpatient admission, with nearly 90% of these patients hospitalized.
From an operational standpoint, rapid triage recognition and immediate isolation were essential for outbreak control. Suspected cases were promptly transferred to dedicated isolation areas, and strict infection-control measures were applied. These strategies helped limit nosocomial transmission despite resource constraints and high patient flow during the outbreak period.
The outbreak highlights measles persistence in unvaccinated adults, with elevated CRP associated to severity. While following a clear measles management protocol in the Emergency Department is key for containing the outbreaks, vaccination remains the most important solution.
This study describes 17 laboratory-confirmed measles cases presenting to an Emergency Department in Barletta during the 2025–2026 outbreak. Data were collected from platforms used by the Emergency Department: Edotto, T-Health Net and AGFA healthcare. Chi-square test was used to assess correlation between laboratory parameters and hospitalization.
These cases were assessed for demographic, clinical, laboratory, radiological, and management characteristics Patients were mainly young adults, all but one were not vaccinated. The great majority of patients had flu-like symptoms, fever being the most frequent sign, and presented to the Emergency Department with the characteristic maculopapular rash. Hepatic involvement was frequent, with elevated transaminases in over 80% of cases, though these were not associated with hospitalization. In contrast, elevated C-reactive protein (≥5 mg/dL) showed a strong association with inpatient admission, with nearly 90% of these patients hospitalized.
From an operational standpoint, rapid triage recognition and immediate isolation were essential for outbreak control. Suspected cases were promptly transferred to dedicated isolation areas, and strict infection-control measures were applied. These strategies helped limit nosocomial transmission despite resource constraints and high patient flow during the outbreak period.
The outbreak highlights measles persistence in unvaccinated adults, with elevated CRP associated to severity. While following a clear measles management protocol in the Emergency Department is key for containing the outbreaks, vaccination remains the most important solution.
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