DTA

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Tesi etd-06142017-092052

Type of thesis
Dottorato
Author
SVEZIA, BENEDETTA
URN
etd-06142017-092052
Title
Study on the effects of microRNAs extracted from Vitis vinfera L. (cv. Sangiovese) grapevine berry on the heart following myocardial infarction: A novel nutraceutical approach.
Scientific disciplinary sector
AGR/07
Course
SCIENZE AGRARIE E BIOTECNOLOGIE - Agrobiodiversity
Committee
relatore Prof. PE', MARIO ENRICO
Keywords
  • C-type natriuretic peptide
  • miRNA
  • myocardial infarction
  • natriuretic peptide system
  • nutraceutical
  • Sangiovese
  • small RNA
  • Vitis vinifera
Exam session start date
;
Availability
completa
Abstract
My research activity is part of a nutraceutical project recently that aims at developing a functional grape juice from berries of Vitis vinifera L. cv Sangiovese with a high concentration of microRNAs, whose target are patients who have suffered a myocardial infarction. The aim of my research work is to evaluate whether the intake of microRNA from Sangiovese berries can protect cardiac cells and improves the heart performance. This work may clarify the cardio-protective effects of grape microRNAs extracted from Vitis vinifera cultivar Sangiovese grapevine and this could provide a completely novel avenue for nutraceutical epigenetic approach based on agrobiodiversity.
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