DTA

Digital Theses Archive

 

Tesi etd-10162023-171159

Type of thesis
Corso Ordinario Ciclo Unico 6 Anni
Author
BEDEIR, NUR
URN
etd-10162023-171159
Title
Apelisib and insulin resistance, a pilot and feasibility study
Structure
Cl. Sc. Sperimentali - Medicina
Course
SCIENZE MEDICHE - SCIENZE MEDICHE
Committee
Tutor Prof. EMDIN, MICHELE
Relatore Prof. COOK, JOSHUA
Presidente Prof. PASSINO, CLAUDIO
Membro Prof.ssa ANGELONI, DEBORA
Membro Prof. RECCHIA, FABIO ANASTASIO
Membro Prof. LIONETTI, VINCENZO
Keywords
  • alpelisib
  • diabetes
  • insulin
  • insulin resistance
  • resistance
Exam session start date
18/12/2023;
Availability
parziale
Abstract
Insulin resistance , encompassing conditions like type 2 diabetes and the metabolic syndrome, is rapidly emerging as one of the major global healthcare burdens. In this context, there's a need for different research methods to delve deeper into its mechanisms. This pilot and feasibility study specifically investigates the potential use of alpelisib (a PI3K inhibitor), a drug primarily known for its use in breast cancer, as a tool to induce a human model of insulin resistance. If successful, alpelisib could serve as a valuable instrument for future steps in the study of insulin resistance and its effects on human metabolism.
Files