DTA

Corso Ordinario Secondo Livello

BONI, EMANUELE

etd-10242022-172823

Molecular circuits underlying peculiar temporal behaviors: from plants and cyanobacteria architectures to synthetic biology counterparts

Cl. Sc. Sperimentali - Agraria

SCIENZE AGRARIE E BIOTECNOLOGIE - SCIENZE AGRARIE E BIOTECNOLOGIE

relatore Prof.ssa PUCCIARIELLO, CHIARA
Membro Prof.ssa Schaerli, Yolanda
Presidente Prof.ssa ERCOLI, LAURA
Membro Prof. DELL'ACQUA, MATTEO
Membro Prof. PERATA, PIERDOMENICO
Membro Prof. SEBASTIANI, LUCA

• double inhibition motif
• gene regulatory networks
• molecular clocks
• oscillators
• synthetic biological systems
• temporal circuits
• temporal filters

15/12/2022;

parziale

The ability to finely control the temporal aspect of biological processes is of the utmost importance for living beings, for example in signal transduction, cell cycle, and embryonic development. Both prokaryotes and eukaryotes display molecular architectures that govern peculiar temporal patterns, such as the vernalization process in plants, and the circadian rhythms in plants and cyanobacteria. The gene regulatory networks underlying such behaviors have been extensively studied, but we lack a comprehensive insight into their dynamics. Most importantly, we need to understand how to manipulate them in order to engineer programmable biological systems, such as biocatalysts, biosensors or biocomputing modules, that operate in a controlled and reliable fashion. Synthetic biology aims to fill this gap using a bottom-up approach, namely by designing and assembling function-oriented temporal circuits composed of well characterized molecular parts.

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