Tesi etd-11112020-091450
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Tipo di tesi
Corso Ordinario Ciclo Unico 6 Anni
Autore
SURDI, PAOLO
URN
etd-11112020-091450
Titolo
Voxel-Based Morphometry and resting state functional connectivity analysis in patients with juvenile myoclonic epilepsy
Struttura
Cl. Sc. Sperimentali - Medicina
Corso di studi
SCIENZE MEDICHE - SCIENZE MEDICHE
Commissione
Tutor Prof. RECCHIA, FABIO ANASTASIO
Relatore Prof. GIORGI, FILIPPO SEAN
Presidente Prof. EMDIN, MICHELE
Membro Dott.ssa CASIERI, VALENTINA
Membro Prof. COCEANI, FLAVIO
Membro Prof. LIONETTI, VINCENZO
Membro Prof. PASSINO, CLAUDIO
Membro Dott.ssa ANGELONI, DEBORA
Membro Dott. MEOLA, MARIO
Membro Dott.ssa PETRUCCI, ILARIA
Membro Dott. GIANNONI, ALBERTO
Relatore Prof. GIORGI, FILIPPO SEAN
Presidente Prof. EMDIN, MICHELE
Membro Dott.ssa CASIERI, VALENTINA
Membro Prof. COCEANI, FLAVIO
Membro Prof. LIONETTI, VINCENZO
Membro Prof. PASSINO, CLAUDIO
Membro Dott.ssa ANGELONI, DEBORA
Membro Dott. MEOLA, MARIO
Membro Dott.ssa PETRUCCI, ILARIA
Membro Dott. GIANNONI, ALBERTO
Parole chiave
- connectivity
- juvenile myoclonic epilepsy
- resting state functional MRI
- voxel-based morphometry
Data inizio appello
14/12/2020;
Disponibilità
completa
Riassunto analitico
Objectives: Juvenile myoclonic epilepsy (JME) is classified as a type of idiopathic generalized epilepsies (IGE), but converging evidence has suggested the existence of possible micro-structural alterations. We aimed to investigate alterations of thalamocortical connectivity in JME patients using thalamic seed-based functional connectivity (FC) analysis, and their relationships with clinical characteristics.
Methods: We studied 17 JME patients (3 males/14 females, mean age 29.9, range 21-49 years) and 13 healthy subjects matched for age, sex and education. Patients and controls performed a 3T MRI scanner that included volumetric morphological sequences and an echo-planar fMRI sequence in resting conditions. Voxel-based morphometry (VBM) was first performed to detect thalamic region of gray matter (GM) reduction in patients compared to controls. Between-group comparison of thalamocortical FC was then carried out using resting-state functional magnetic resonance imaging (rs-fMRI) analysis seeding at thalamic region of volume difference. A series of neuropsychological tests and some clinical data (previous GTCS, duration of illness, mono-/polytherapy) were used as covariates in intra- group connectivity analysis.
Results: VBM analysis detected a bilateral GM reduction in the anteromedial thalamus in JME patients compared to controls. FC analysis seeding at the anteromedial thalamus revealed a thalamocortical FC decrease in the right medial prefrontal cortex and precuneus/posterior cingulate cortex in JME patients compared to controls. In patients with previous occurrence of GTCS and in polytherapy, we identified an increase in FC with bilateral frontal cortical areas.
Conclusions: In JME patients there are structural and resting state functional connectivity alterations with the anteromedial thalamus which could have potential pathophysiological and neuropsychological implications.
Methods: We studied 17 JME patients (3 males/14 females, mean age 29.9, range 21-49 years) and 13 healthy subjects matched for age, sex and education. Patients and controls performed a 3T MRI scanner that included volumetric morphological sequences and an echo-planar fMRI sequence in resting conditions. Voxel-based morphometry (VBM) was first performed to detect thalamic region of gray matter (GM) reduction in patients compared to controls. Between-group comparison of thalamocortical FC was then carried out using resting-state functional magnetic resonance imaging (rs-fMRI) analysis seeding at thalamic region of volume difference. A series of neuropsychological tests and some clinical data (previous GTCS, duration of illness, mono-/polytherapy) were used as covariates in intra- group connectivity analysis.
Results: VBM analysis detected a bilateral GM reduction in the anteromedial thalamus in JME patients compared to controls. FC analysis seeding at the anteromedial thalamus revealed a thalamocortical FC decrease in the right medial prefrontal cortex and precuneus/posterior cingulate cortex in JME patients compared to controls. In patients with previous occurrence of GTCS and in polytherapy, we identified an increase in FC with bilateral frontal cortical areas.
Conclusions: In JME patients there are structural and resting state functional connectivity alterations with the anteromedial thalamus which could have potential pathophysiological and neuropsychological implications.
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