DTA

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Tesi etd-11132020-234507

Type of thesis
Corsi integrativi di II livello
Author
VICARI, ELENA
URN
etd-11132020-234507
Title
Mechanistic modeling suggests that low-intensity focused ultrasound can selectively recruit myelinated or unmyelinated nerve fibers
Structure
Cl. Sc. Sperimentali - Ingegneria
Course
INGEGNERIA - INGEGNERIA
Committee
relatore Prof. CIPRIANI, CHRISTIAN
Relatore Prof. MICERA, SILVESTRO
Presidente Prof. FRISOLI, ANTONIO
Membro Prof. STEFANINI, CESARE
Membro Dott. AVIZZANO, CARLO ALBERTO
Membro Prof. BUTTAZZO, GIORGIO CARLO
Membro Prof. CASTOLDI, PIERO
Membro Prof. CUCINOTTA, TOMMASO
Membro Prof. DI PASQUALE, FABRIZIO CESARE FILIPPO
Membro Prof.ssa MENCIASSI, ARIANNA
Keywords
  • electrical stimulation
  • LIFUS
  • modeling
  • neuromodulation
  • peripheral fiber
  • SONIC model
  • ultrasound
Exam session start date
14/12/2020;
Availability
parziale
Abstract
Focused ultrasound stimulation has recently emerged as a promising selective, reversible, and non-invasive neuromodulation technique. However, model predictions concerning the behaviour of morphologically realistic neural structures are still not available.<br>For this reason, we developed a computational framework to model intramembrane cavitation in multi-compartmental, morphologically-realistic neuronal representations, and used it to investigate the response of peripheral axons to spatially-varying pressure fields. Our model predictions show that ultrasonic stimulation offers distinct parametric sub-spaces to selectively recruit myelinated or unmyelinated neural fibers and modulate their spiking activity over physiologically relevant regimes. <br>This singular feature suggests that acoustic stimulation could preferentially target nociceptive and sensory fibers to enable peripheral therapeutic applications not addressable by electric stimulation. These results open up new opportunities for the development of more selective and effective peripheral neuroprostheses.
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